2013 Fiscal Year Final Research Report

The study of activation of innate immune response by dietary nucleic acids via oral mucosa

Research Project

Project/Area Number	23617001
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Integrated Nutrition Science
Research Institution	Hokkaido University
Principal Investigator	KAMEYAMA Takeshi 北海道大学, 遺伝子病制御研究所, 研究員 (40569505)
Co-Investigator(Kenkyū-buntansha)	HAYAKAWA Sumio 北海道大学, 遺伝子病制御研究所, 助教 (00368292) ADACHI Yoshihiro Christopher 北海道大学, 遺伝子病制御研究所, 博士研究員 (10616204)
Co-Investigator(Renkei-kenkyūsha)	TAKAOKA Akinori 北海道大学, 遺伝子病制御研究所, 教授 (30323611)
Research Collaborator	OKADA Kanako 北海道大学, 理学部, 修士 TODA Haruka 北海道大学, 理学部, 学生
Project Period (FY)	2011 – 2013
Keywords	自然免疫 / 食餌性核酸 / インターフェロン / 口腔粘膜
Research Abstract	Diet contains various kinds of nutrient,, which keep us healthy. However the nutritional role of nucleic acids derived from diets is not clearly understood. The innate immunity system is an essential step as the front line of host defense. Although oral mucosa acts as powerful barriers, the importance of oral mucosa in innate immunity remains unclear. In this study, we demonstrate that DNA derived from vegetable activated innate immune response both in vitro and in vivo, which may provide the nutritional immunological role of dietary nucleic acids.

(4 results)