2013 Fiscal Year Final Research Report
The elucidation of the impaired glucose tolerance mechanism to occur frequently in a thin youth woman
| Project/Area Number |
23617031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 糖尿病 / インクレチン / インスリン分泌 / 食習慣 |
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| Research Abstract |
We investigated the situation of impaired glucose tolerance (IGT) in young Japanese women and examined whether adoption of optimal carbohydrate intake could lead to improved IGT. We conducted a 75-g oral glucose tolerance test with 412 women enrolled at N University in Aichi Japan. IGT was found in 30.3% of the participants despite their young age. An open intervention study was conducted for 3 months with 26 of the women found to have IGT. The intervention was optimal carbohydrate intake based on body height 3 times per day.
After the intervention, Glucagon-like peptide-1 level at 30 min and insulinogenic index was significantly increased, and plasma glucose level at 30 and 60 min and HbA1c were significantly decreased. These data suggest that the adoption of optimal carbohydrate intake could lead to increased insulin secretion and improve IGT in young women.
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