2012 Fiscal Year Final Research Report
A new preventive way on diseases using electronic chaperones as a novel concept
| Project/Area Number |
23650269
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAI Hirofumi 熊本大学, 大学院・生命科学研究部, 教授 (30194658)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 微弱電流 / TRP family / ラフト構造 / インスリン受容体 |
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| Research Abstract |
Our previous report showed that mild electrical stress (MES)enhanced the insulin-induced signaling pathway. However, the molecular mechanism of theeffect of MES remains unclear. We assessed the effect of MES, which is characterized bylow-intensity direct current, on insulin signaling in vitro and in vivo. Here we showedthat MES activated the insulin signaling in an insulin-independent manner, and improvedinsulin resistance in peripheral tissues of high fat-fed mice. Moreover, we found thatMES increased the localization of IR in lipid rafts and enhanced the level ofphosphorylated Akt in insulin-resistant hepatic cells. Ablation of lipid rafts disruptedthe effect of MES on Akt activation
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Research Products
(18 results)
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[Journal Article] Insulinreceptor activation through itsaccumulation in lipid rafts by mildelectrical stress.2012
Author(s)
Morino-Koga S, Yano S, Kondo T,Shimauchi Y, Matsuyama S, Okamoto Y,Suico MA, Koga T, Sata T, Shuto T, ArimaH, Wada I, Araki E, Kai H.
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Journal Title
J. Cell. Physiol
Volume: 228
Pages: 439-446
Peer Reviewed
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[Journal Article] Hyperthermia With MildElectrical Stimulation ProtectsPancreatic β -Cells From CellStresses and Apoptosis.2012
Author(s)
Kondo T, Sasaki K, Matsuyama R,Morino-Koga S, Adachi H, Suico MA,Kawashima J, Motoshima H, Furukawa N,Kai H, Araki E.
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Journal Title
Diabetes
Volume: 61
Pages: 838-47
Peer Reviewed
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[Journal Article] GlucoseUptake in Rat Skeletal Muscle L6 CellsIs Increased by Low-IntensityElectrical Current Through theActivation of thePhosphatidylinositol-3-OH kinase(PI-3K) / Akt Pathway.2011
Author(s)
Yano S, Morino-Koga S, Kondo T, SuicoMA, Koga T, Shimauchi Y, Matsuyama S,Shuto T, Sato T, Araki E, Kai H.
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Journal Title
J Pharmacol Sci
Volume: 115(1)
Pages: 94-8
Peer Reviewed
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[Presentation] 遺伝性糸球体腎疾患アルポト症候群に対する新たなphysical medicine の腎病態改善効果2013
Author(s)
甲斐 友佳理, 古賀 友紹, 福田 亮介, 古賀 沙緒里, Mary Ann SUICO,小山 皓介, 松山 真吾, 佐藤 卓史,首藤 剛, 甲斐 広文
Organizer
日本薬学会第133 年会
Place of Presentation
パシフィコ横浜,(横浜)
Year and Date
20130327-30
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