2013 Fiscal Year Final Research Report
Novel super-rapid screening method to customize the cellular medium ingredients based-on cell morphology analysis
| Project/Area Number |
23650286
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya University |
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Principal Investigator |
KATO Ryuji 名古屋大学, 創薬科学研究科, 准教授 (50377884)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Ichiro 名古屋工業大学, 工学研究科, 准教授 (40335146)
KAGAMI Hideaki 東京大学医科学研究所, 先端医療研究センター分子療法分野, 特任准教授 (80242866)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 培地開発 / 細胞形態情報解析 / 形態分類 / パターニング / クラスタリング / 多変量解析 / 培地最適化 / 再生医療 |
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| Research Abstract |
This research was conducted to develop effective and rapid screening method for designing novel cell culture medium for regenerative medicine or medical development. Briefly, we applied the cellular morphological bioinformatics analysis method to numerically convert the cellular response to indicate the surrounding effects from medium. As a result, we found that clustering-based morphological analysis can categorize the medium effects, also with the combination with cellular activity, and established a screening strategy to evaluate the medium additives non-invasively and rapidly. We also found several compounds could stably control the stem cell differentiation through our method.
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[Presentation] 細胞画像解析による継代培養における細胞ダメージ度評価
Author(s)
佐々木 寛人, 加藤竜司, 蟹江 慧, 名倉良英, 塩野 博文, 紀伊 宏昭, 魚住 孝之, 越馬 隆治, 清田 泰次郎, 富岡 研, 本多 裕之
Organizer
第63回生物工学会大会
Place of Presentation
東京農工大学, 東京
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