2012 Fiscal Year Final Research Report
Nutrient transceptor;gate keepers of regulators of nutrient signaling
| Project/Area Number |
23650480
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIYAMOTO Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (70174208)
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| Project Period (FY) |
2011 – 2012
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| Keywords | カルシウム / リン / トランスセプター / 破骨細胞 / 栄養 / 腎臓 |
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| Research Abstract |
The discovery of transporter-related receptors, now called transceptors, has raised interesting questions with respect to their functions. In the present study, we investigated whether XPR1 and SLC34A3 functions as calcium/inorganic phosphate transceptor in mammalian cells. Our results indicate that XPR1 is a novel transceptor and that XPR1 participates in G-protein-mediated cAMP signaling.
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[Journal Article] Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats2012
Author(s)
Van TV, Watari E, Taketani Y, Kitamura T, Shiota A, Tanaka T, Tanimura A, Harada N, Nakaya Y, Yamamoto H, Miyamoto K, Takeda E
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Journal Title
J Clin Biochem Nutr
Volume: 51(1)
Pages: 27-32
DOI
Peer Reviewed
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[Journal Article] Identification and functional analysis of a splice variant of mouse sodium- dependent phosphate transporter Npt2c2012
Author(s)
Kuwahara S,Aranami F,Segawa H,Onitsuka A,Honda N,Tominaga R,Hanabusa E,Kaneko I,Yamanaka S,Sasaki S,Ohi A,Nomura K,Tatsumi S,Kido S,Ito M,Miyamoto K.
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Journal Title
J Med Invest
Volume: 59(1-2)
Pages: 116-126
DOI
Peer Reviewed
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[Journal Article] Processing and stability of type IIc sodium-dependent phosphate cotransporter mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria2011
Author(s)
Haito-Sugino S, Ito M, Ohi A, Shiozaki Y, Kangawa N, Nishiyama T, Aranami F, Sasaki S, Mori A, Kido S, Tatsumi S, Segawa H, Miyamoto KI
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Journal Title
Am J Physiol Cell Physiol
Volume: 302(9)
Pages: C1316-1330
DOI
Peer Reviewed
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[Journal Article] Inorganic phosphate homeostasis in sodium-dependent phosphate co- transporter Npt2b+/- mice2011
Author(s)
Ohi A, Hanabusa E, Ueda O, Segawa H, Horiba N, Kaneko I, Kuwahara S, Mukai T, Sasaki S, Tominaga R, Furutani J, Aranami F, Ohtomo S, OikawaY, Kawase Y, Wada NA, Tachibe T, Kakefuda M, Tateishi H, Matsumoto K, Tatsumi S, Kido S, Fukushima N, Jishage KI,Miyamoto K.
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Journal Title
Am J Physiol Renal Physiol
Volume: 301(5)
Pages: F1105-1113
DOI
Peer Reviewed
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[Journal Article] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats.2011
Author(s)
Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Ito M, Miyamoto K, Tsuji A, Kawai Y, Terao J
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Journal Title
Free Radic Biol Med
Volume: 51(7)
Pages: 1329-1336
Peer Reviewed
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[Journal Article] Sodium-dependent phosphate cotransporters: Lessons from gene knockout and mutation studies2011
Author(s)
Miyamoto K, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I, Segawa H
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Journal Title
J Pharm Sci
Volume: 100(9)
Pages: 3719-3730
DOI
Peer Reviewed
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[Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis2011
Author(s)
Tanimura A, Yamada F, Saito A, Ito M, Kimura T, Anzai N, Horie D, Yamamoto H, Miyamoto K, Taketani Y, Takeda E
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Journal Title
J Ned Invest
Volume: 58(1-2)
Pages: 140-147
DOI
Peer Reviewed
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