2013 Fiscal Year Final Research Report
Development of Synthetic Host Molecule Aiming to Artificial Enzymes for Sugar Synthesis
| Project/Area Number |
23655124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional materials chemistry
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| Research Institution | University of Toyama |
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Principal Investigator |
ABE Hajime 富山大学, 大学院医学薬学研究部(薬学), 准教授 (10324055)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUYE Masahiko 富山大学, 大学院・医学薬学研究部, 教授 (60211752)
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| Project Period (FY) |
2011 – 2013
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| Keywords | エチニルピリジン / 大環状化合物 / ピリジン / フェノール / 糖 / ホスト・ゲスト化学 / 薗頭反応 |
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| Research Abstract |
Pyridine-phenol alternating macrocyclic oligomers, which were designed for strong saccharide recognition ability, have been developed in this research. The qualitative study on 1H NMR and DFT calculation studies suggested that the saccharide recognition ability is much stronger than we expected before the project. However, the self-aggregation of the host was a serious problem for saccharide recognition. So the effect of steric hindrance was examined by introducing tert-butyl and 2,4,6-triisopropylphenyl groups on the host macrocycle. Finally, it was found that the association constant between the host and octyl glucoside achieved up to 900,000 /M.
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