2012 Fiscal Year Final Research Report
Extinction of constitutive heterochromatin blocks in humans: structural analysis for clarification of mechanisms
| Project/Area Number |
23657165
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical anthropology
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| Research Institution | Kyoto University |
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Principal Investigator |
KOGA Akihiko 京都大学, 霊長類研究所, 教授 (80192574)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 染色体 / 反復配列 / ヘテロクロマチン / セントロメア / テロメア |
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| Research Abstract |
This study deals with rapid changes in the amount of constitutive heterochromatin, including emergence, amplification, reduction and extinction. These changes are frequently observed in many primate groups, such as hominids and gibbons. Cloning, sequencing and hybridization experiments revealed that such rapid changes are associated with integration of repetitive sequencesinto the centromere or telomere and the speed of change depends on their nucleotide sequences.
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