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2013 Fiscal Year Final Research Report

Molecular regulation of epigenetics of the cytochrome P450 genes by food chemicals

Research Project

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Project/Area Number 23658116
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionKobe University

Principal Investigator

IMAISHI Hiromasa  神戸大学, 学内共同利用施設等, 教授 (50223318)

Project Period (FY) 2011 – 2013
KeywordsP450
Research Abstract

It is known that P450 which is a useful biological catalyst can carry out the monooxigenation of the medicine and chemicals.Especially P450 can carry out metabolic activation of various chemical substances which participate in the generation of cancer cells. We know that the chemical substance with has mutagenicity can increase the cancer cells in our body. In general, these mutagenic chemicals are metabolic activated by P450 monooxygenase. On the other hand, there is a little information about the mechanism for the activation of non-mutagenic chemicals. In this research, we show that the isothiocyanate which is a non-mutagenicity substance of food origin can regulate the total amount of mRNA of P450.

  • Research Products

    (5 results)

All 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Predicting Toxicity of Food-Related Compounds Using Fuzzy Decision Trees2013

    • Author(s)
      Yajima, D., Ohkawa, T., Muroi, K., Imaishi, H
    • Journal Title

      International Journal of Bioscience, Biochemistry and Bioinformatics

      Volume: 4(1) Pages: 33-38

    • Peer Reviewed
  • [Journal Article] Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants2012

    • Author(s)
      Uno, T., Obe, Y., Ogura, C., Goto, T., Yamamoto, K., Nakamura, M., Kanamaru, K., Yamagata, H., Imaishi, H
    • Journal Title

      Biopharm. Drug Dispos

      Volume: 34 (2) Pages: 87-97

    • Peer Reviewed
  • [Presentation] ヒト P450 発現大腸菌を用いた Umu-test による食品関連化合物の変異原性2013

    • Author(s)
      室井康平, 森大気, 後藤達志, 澤田夏美, 今石浩正
    • Organizer
      P450, UGT, SALT研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2013-06-06
  • [Presentation] P450反応パターン解析を用いた食品関連化合物の毒性予測2013

    • Author(s)
      今石浩正
    • Organizer
      P450, UGT, SALT研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2013-06-06
  • [Remarks]

    • URL

      http://www.research.kobe-u.ac.jp/rceg-nowstone/index.html

URL: 

Published: 2015-06-25  

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