2012 Fiscal Year Final Research Report
Development of triple-target antitumor drugs recognized by oligopeptide transporters
| Project/Area Number |
23659019
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
KATO Yukio 金沢大学, 薬学系, 教授 (30251440)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMICHI Noritaka 金沢大学, 薬学系, 准教授 (10401895)
SUGIURA Tomoko 金沢大学, 薬学系, 助教 (70542190)
WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ペプチド / トランスポーター / PDZアダプター / 抗腫瘍薬 / 生体膜透過 |
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| Research Abstract |
Transporters play pivotal roles in both uptake of nutrients and efflux of metabolites/xenobiotics in the body. Oligopeptide transporters (PEPT) function as an uptake mechanism for both dipeptides and tripeptides. PEPTs are known to be highly expressed in a certain types of cancer cells probably to maintain its extremely rapid growth by uptake of nutrients. We have previously succeeded in synthesis of both tumor-imaging substrate and anti-tumor peptides targeted to PEPTs. In the present study we aimed to establish antitumor drugs with triple targets of PEPTs and its associated proteins.
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