2012 Fiscal Year Final Research Report
Investigation of the mechanism of insulin secretion via Ca
| Project/Area Number |
23659049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHUTO Satoshi 北海道大学, 大学院・薬学研究院, 教授 (70241346)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAWAKI Ken 北海道大学, 大学院・薬学研究院, 特任助教 (60451407)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 医薬分子設計 |
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| Research Abstract |
As the key molecule to develop effective biological tools for theidentification of target proteins of cADPR in cells, 4” α-aziceethyl-cADPcR (3) was designedand successfully synthesized. 4” α-Azidoethyl-cADPcR (3) was shown to be biologically activeas we expected.
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[Journal Article] Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Ca-Mobilizing Second Messenger
Author(s)
T. Tsuzuki, N. Sakaguchi, T. Kudoh, S. Takano, M. Uehara, T. Murayama, T. Sakurai, M. Hashii, H. Higashida, K. Weber, A. H. Guse, T. Kameda, T. Hirokawa, Y. Kumaki, B. V. L. Potter,H. Fukuda, M. Arisawa, S. Shuto
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Journal Title
Angew.Chem. Int. Ed
Volume: (印刷中)
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