2012 Fiscal Year Final Research Report
Development of a novel approach toward nucleic acids-based therapeutics
| Project/Area Number |
23659054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MINAKAWA Noriaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40209820)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Koji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00184656)
YAMAZAKI Naoshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (20271083)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ゲノム創薬 |
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| Research Abstract |
In this work, we aimed to prepare novel chemically modified RNA molecules possessing nuclease resistance and hybridization ability. In addition, we expected that these molecules exhibit editing ability of splicing abnormality. As a result, the resulting hybrid type of 4’-thionucleic acids showed preferable properties concerning of nuclease resistance and hybridization ability. Among the hybrid type of 4’-thionucleic acids developed, 2’-F-2’-thioRNA showed U1i activity arising from recruitment of U1 snRNA on pre-mRNA. Toward the end goal, we investigated the preparation of head-to-head oligonucleotides.
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