2012 Fiscal Year Final Research Report
Disruption of vascular integrity by deficiency of PI3K class II αisoform in mice
| Project/Area Number |
23659170
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKUWA Yoh 金沢大学, 医学系, 教授 (60171592)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIOKA Kazuaki 金沢大学, 医学系, 助教 (80333368)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子病態学 / PI 3-キナーゼ / 小胞輸送 / 血管恒常性 / 血管障壁機能 / 血管透過性 / 動脈瘤 / アナフィラキシー |
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| Research Abstract |
Class II α isoform of phosphatidylinositol 3-kinase (PI3K-C2α) plays the essential role for vesicular trafficking in vascular endothelial cells. In PI3K-C2α-deleted mice, vascular permeability increase after administration of edematogenic mediator was exaggerated compared with wild-type mice. PI3K-C2α-deleted mice also showed a higher frequency of the formation of dissecting aortic aneurysms. Thus, PI3K-C2α is crucial for maintaining vascular integrity through the distinct action from that of class I PI3K, and suggested to be a potential useful therapeutic target for vascular diseases.
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[Journal Article] Essential role of endothelial class II PI3K-C2α in angiogenesis and vascular barrier function2012
Author(s)
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz J.R, Okamoto H, Sasaki T, Matsui O, Asano M, Adams H.R, Takakura N, Takuwa Y
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Journal Title
Nature med
Volume: 18(10)
Pages: 1560-1569
Peer Reviewed
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[Presentation] Endothelial PI3K-C2a2013
Author(s)
Yoh Takuwa
Organizer
a class II PI3K in angiogenesis and vascular barrier function Gordon Reseach Conference Vascular Cell Biology
Place of Presentation
Four Points Sheraton / Holiday Inn Express Express Ventura, (U.S.A)
Year and Date
20130127-0201
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[Presentation] Endothelial PI3K-C2a2013
Author(s)
Yoshioka K, Yoshida K, Biswas K, Takuwa Y, et al
Organizer
a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Gordon Reseach Conference Vascular Cell Biology
Place of Presentation
Four Points Sheraton / Holiday Inn Express Express Ventura, (U.S.A)
Year and Date
20130127-0201
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[Presentation] ClassII PI3-kinase2013
Author(s)
Kuntal Biswas, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa and Yoh Takuwa
Organizer
PI3K-C2alpha, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation Gordon Reseach Conference Vascular Cell Biology
Place of Presentation
Four Points Sheraton / Holiday Inn Express Express Ventura, (U.S.A)
Year and Date
20130127-0201
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[Presentation] Endothelial class II PI3K-Ca2a has an essential role for physiological and pathological angiogenesis2011
Author(s)
Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Xun Qi, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Kazushi Sugihara, Sho Aki, Kuntal Biswas, Masahide Asano, Yo h Takuwa
Organizer
日本分子生物学会第11回春季シンポジウム ポスタ
Place of Presentation
石川県立音楽堂(石川県)
Year and Date
20110525-26
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