Biological studies of size-effect by nano-particles

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659203
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Kyoto University
• Principal Investigator: INABA Kayo 京都大学, 大学院・生命科学研究科, 教授 (00115792)
• Co-Investigator(Kenkyū-buntansha): TAKAHARA Kazuhiko 京都大学, 大学院・生命科学研究科, 講師 (90301233)
• Project Period (FY): 2011 – 2012
• Keywords: 炎症

Research Abstract

Small particles, such as asbestos and silica, cause inflammatory cellular responses, leading to various types of diseases. In this study, we investigated production mechanism of pro-inflammatory cytokine IL-1β. Using size-fractionated silica particles and size-defined latex beadsas stimulators, it was indicated that bone marrow-derived macrophagesuse distinct cellular pathway of IL-1βproduction in a particle size-dependent manner.

Research Products

• [Journal Article] Identification of a novel type 2 innate immunocyte with the ability to enhance IgE production (2013)
  • Author(s): Fukuoka, A., Futatsugi-Yumikura, S., Takahashi, S., Kazama, H., Iyoda, T., Yoshimoto, T., Inaba. K., Nakanishi, K. and Yonehara S
  • Journal Title: Int. Immunol Volume: (in press)
  • DOI: doi:10.1093/intimm/dxs160
  • Peer Reviewed
• [Journal Article] A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential (2013)
  • Author(s): Onai, N., Kurabayashi, K., Hosoi-Amaike, M., Toyama-Sorimachi, N., Matsushima, K., Inaba, K. and Ohteki T
  • Journal Title: Immunity Volume: (in press)
  • DOI: doi:10.1016/j.immuni.2013.04.006
  • Peer Reviewed
• [Journal Article] IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms (2012)
  • Author(s): Minamino, K., Takahara, K., Adachi, T., Nagaoka, K., Iyoda, T., Taki, S. and Inaba, K.
  • Journal Title: Int. Immunol Pages: 573-581
  • DOI: doi:10.1093/intimm/dxs060
  • Peer Reviewed
• [Journal Article] Efficient capture of C. albicans and zymosan by SIGNR1 facilitates TLR2-dependent TNF-αproduction by macrophages. (2012)
  • Author(s): Takahara, K., Tokieda, S., Nagaoka, K. and Inaba, K
  • Journal Title: Int. Immunol Volume: 24 Pages: 89-96
  • DOI: doi:Int. Immunol
  • Peer Reviewed
• [Journal Article] Sulfatide inhibits α-galactosylceramide presentation by dendritic cells (2012)
  • Author(s): Kanamori, K., Tasumi, Y., Iyoda, T., Ushida, M. and Inaba, K.
  • Journal Title: Int. Immunol Volume: 24 Pages: 129-136
  • DOI: doi:10.1093/intimm/dxr108
  • Peer Reviewed
• [Journal Article] Difference in fine specificity to polysaccharides of C. albicans mannoprotein between mouse SIGNR1 and human DC-SIGN (2012)
  • Author(s): Takahara, K., Arita, T., Tokieda, S., Shibata, N., Okawa, Y., Tateno, H., Hirabayashi, J. and Inaba, K
  • Journal Title: Infect. Immun Volume: 80 Pages: 1699-1706
  • DOI: doi:10.1128/​IAI.06308-11
  • Peer Reviewed
• [Journal Article] Langerhans cells are critical in epicutaneous sensitization with protein antigen via TSLP receptor signaling. (2012)
  • Author(s): Nakajima, S., Igyarto, B., Honda, T., Egawa, G.,Otsuka, A., Hara-Chikuma, M., Watanabe, N., Ziegler, S. F., Tomura, M., Inaba, K., Miyachi, Y., Kaplan, D. H. and Kabashima, K.
  • Journal Title: J. Allergy Clin. Immunol Volume: 129 Pages: 1048-1055
  • DOI: doi:10.1016/j.jaci.2012.01.063
  • Peer Reviewed
• [Journal Article] GM-CSF-independent CD1a expression in epidermal Langerhans cells: evidence from human CD1A genome-transgenic mice (2012)
  • Author(s): Kobayashi, C., Shiina, T., Tokioka, A., Hattori, Y., Komori, T., K o b a y a s h i-Miura, M., Takizawa, T., Takahara, K., Inaba, K., Inoko, H., Takeya, M., Dranoff, G. and Sugita, M
  • Journal Title: J. Invest. Dermatol Volume: 132 Pages: 241-244
  • DOI: doi:10.1038/jid.2011.280
  • Peer Reviewed
• [Presentation] 樹状細胞研究 基礎から臨床への架け橋 (2013)
  • Author(s): 稲葉 カヨ
  • Organizer: 日本免疫治療学研究会(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2013-02-09
• [Presentation] IRF-2 controls antibody production through upregulation of Blimp-1 and class switch recombination (2012)
  • Author(s): 南野 研人、高原 和彦、足立 匠、長岡 孝治、伊豫田 智典、瀧 伸介、稲葉 カヨ
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] Pretreatment with low dose αGC enhanced IFN-γ production by iNKT cells (2012)
  • Author(s): 伊豫田 智典、牛田 万貴、金森 光広、稲葉 カヨ
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] Identification of human dendritic cells producing a high level of retinoic acid (2012)
  • Author(s): 佐藤孝之、北脇年雄、伊豫田智典、稲葉カヨ、岩田誠、樗木俊聡、高折晃史、門脇則光
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] Distinctive IL-1β production mechanisms depending on nano- and micro-size particles (2012)
  • Author(s): 足立 匠、高原 和彦、種子尾 潤、稲葉 カヨ
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] Dysfunction of IFN system causes susceptibility to infection in patient with MPO-ANCA-associated vaculitis (2012)
  • Author(s): 宇野 賀津子、武曾絵里、猪原敏子、稲葉 カヨ、鈴木和男
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] Human C-type lectin DC-SIGN recognizes C. albicans more efficiently than S. cerevisiae and produces a large amount of IL-10 (2012)
  • Author(s): 高原 和彦、稲葉 カヨ
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] 樹状細胞研究の道 (2012)
  • Author(s): 稲葉 カヨ
  • Organizer: 日本ハイオセラピィ学会(招待講演)
  • Place of Presentation: 倉敷
  • Year and Date: 2012-12-03
• [Presentation] My memory of Ralph and the initiation of his work on dendritic cells (2012)
  • Author(s): 稲葉 カヨ
  • Organizer: International Symposium on Dendritic cells(招待講演)
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2012-10-11
• [Presentation] 樹状細胞による免疫応答の始動と調節 (2012)
  • Author(s): 稲葉 カヨ
  • Organizer: 小児アレルギー学会(招待講演)
  • Place of Presentation: 大阪
  • Year and Date: 2012-09-16
• [Presentation] ノーベル賞に至る樹状細胞研究の発展 (2012)
  • Author(s): 稲葉 カヨ
  • Organizer: 日本樹状細胞研究会(招待講演)
  • Place of Presentation: 福島
  • Year and Date: 2012-06-15
• [Presentation] Dysfunction of IFN system causes susceptibility to infection in patients with MPO-ANCA-associated vasculitis (2012)
  • Author(s): 宇野 賀津子、武曾絵里、猪原敏子、尾松芳樹、稲葉 カヨ、八木克巳、鈴木和男
  • Organizer: The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
  • Place of Presentation: 東京カンファレンスセンター品川(東京)
  • Year and Date: 2012-03-29
• [Presentation] Dendritic cells in inflammation and immune responses (2012)
  • Author(s): 稲葉 カヨ
  • Organizer: The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012(招待講演)
  • Place of Presentation: 東京カンファレンスセンター品川(東京)
  • Year and Date: 2012-03-28
• [Presentation] 樹状細胞研究の歴史と今後 (2012)
  • Author(s): 稲葉 カヨ
  • Organizer: 愛知県心身障害者コロニー公開セミナー(招待講演)
  • Place of Presentation: 愛知県心身障害者コロニー(春日井市)
  • Year and Date: 2012-02-10
• [Presentation] 粒子サイズによる細胞応答性の差異 -細胞には粒子の大きさに依存した応答経路が存在する- (2012)
  • Author(s): 高原 和彦、足立 匠、種子尾 潤、稲葉 カヨ
  • Organizer: ナノ材料の安全性・社会受容に関するシンポジウム(招待講演)
  • Place of Presentation: 京都リサーチパーク
  • Year and Date: 2012-01-24
• [Presentation] Sulfatideによる樹状細胞のα-galactosylceramideの提示の阻害 (2011)
  • Author(s): 金森 光広、伊豫田 智典、牛田 万貴、稲葉 カヨ
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] C型レクチンSIGNR1はDectin-1と共同して細胞のoxidative burstを促進する (2011)
  • Author(s): 高原 和彦、時枝 純佳、稲葉 カヨ
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] 樹状細胞を介するinvariant natural killer T細胞の寛容誘導 (2011)
  • Author(s): 伊豫田 智典、稲葉 カヨ
  • Organizer: 第21回日本サイトメトリー学会(招待講演)
  • Place of Presentation: 京都市国際交流会館(京都)
  • Year and Date: 2011-06-25
• [Book] 『感染・炎症・免疫』樹状細胞発見の歴史と研究の展開 (2012)
  • Author(s): 稲葉カヨ
  • Total Pages: 300-311
  • Publisher: 医薬の門社
• [Book] 『炎症と免疫』樹状細胞の同定と獲得免疫におけるその役割の発見 (2012)
  • Author(s): 稲葉カヨ
  • Total Pages: 615-620
  • Publisher: 先端医学社
• [Book] 『日本臨床』炎症と免疫応答における樹状細胞 (2012)
  • Author(s): 稲葉カヨ
  • Total Pages: 567-574
  • Publisher: 日本臨牀社
• [Remarks]
  • URL: http://zoo.zool.kyoto-u.ac.jp/imm/