2012 Fiscal Year Final Research Report
Application of adipose tissue-derived mesenchymal stem cells to antimicrobial therapy
| Project/Area Number |
23659217
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hirosaki University |
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Principal Investigator |
NAKANE Akio 弘前大学, 医学(系)研究科(研究院), 教授 (30164239)
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| Co-Investigator(Renkei-kenkyūsha) |
ASANO Krisana 弘前大学, 医学(系)研究科(研究院), 助教 (70598622)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 感染症 / 炎症 / 幹細胞 / 脂肪組織 / 免疫 |
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| Research Abstract |
Therapeutic efficacy of adipose tissue-derived mesenchymal stem cells (ASCs) on lethal bacterial infectious diseases was investigated. Injection of ASCs rescued mice from lethal staphylococcal enterotoxin shock. ASCs suppressed the production of proinflammatory cytokines. This study suggests that ASCs may apply to prevention andtherapy for lethal bacterial infectious diseases.
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