2012 Fiscal Year Final Research Report
Study of novel HIV restriction factors
| Project/Area Number |
23659229
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | AIDS / HIV / restriction factor / SAMHD1 / Vpx / マクロファージ / HSV |
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| Research Abstract |
Accumulating evidences have suggested that the host cells possess intrinsic anti-viral factors. SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, a double stranded DNA viruses, herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. This study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses as well as retroviruses that infect non-dividing myeloid cells during infection.
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Research Products
(19 results)
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[Journal Article] A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice2011
Author(s)
Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y
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Journal Title
Blood
Volume: 117
Pages: 5663-5673
DOI
Peer Reviewed
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[Journal Article] Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity2011
Author(s)
Yamamoto SP, Okawa K, Nakano T, Sano K, Ogawa K., Masuda T, Morikawa Y, Koyanagi Y, Suzuki Y
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Journal Title
Microbes Infect
Volume: 13
Pages: 339-349.
DOI
Peer Reviewed
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