2012 Fiscal Year Final Research Report
Evaluation of drug safety among pregnant women with antihypertensive drugs
| Project/Area Number |
23659347
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KIKUYA Masahiro 東北大学, 東北メディカルメガバンク機構, 准教授 (80361111)
METOKI Hirohito 東北大学, 東北メディカルメガバンク機構, 講師 (20580377)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 妊娠高血圧 / 圧薬 / 市販後調査 / 副作用 / 胎児 |
|---|
| Research Abstract |
[Background] Pregnancy-induced hypertension (PIH) occurs in 5-10% of pregnant women, but information about antihypertensive drugs prescribed to patients with PIH is limited. [Objective] To clarify the prescription of antihypertensive drugs to pregnant women based on claims data. [Methods] We used health insurance claim (claims) data between January 1,2008 and May 31, 2010 at the Japan Medical Data Center. Pregnant women were detected by the information about health insurance claim (claims) data. Pregnancy duration for each woman was estimated by pregnancy week number, start date of medical care in claims for the mothers. Information on drug prescriptions during pregnancy was extracted from medical records or records of dispensed prescriptions. Prescription of antihypertensive drugs during pregnancy was evaluated among all pregnant women and pregnant women with a hypertension-related diagnosis (ICD-10 classification: O10-O16), respectively. [Results] We identified 19,282 pregnant women
… More
(mean age; 30.5±4.7 years, 15.6-49.4 years) from about 90 million health insurance claim (claims) data. Of these, 744 women (0.04%) had been prescribed an antihypertensive drug during pregnancy. The most frequently prescribed antihypertensive drugs during total pregnancy period, first trimester, second trimester, and third trimester were ‘Furosemide’(n=328), ‘Methyldopa’(n=13), ‘Methyldopa’(n=25), ‘Furosemide’(n=299) , respectively. Among 19,282 pregnant women, 1101 pregnant women were diagnosed as hypertension during pregnancy (ICD-10 classification: O10-O16). Of these, 161 women(14.6％) had been prescribed an antihypertensive drug during pregnancy. The most frequently prescribed antihypertensive drugs during total pregnancy period, first trimester, second trimester, and third trimester were ‘Nifedipine’(n=63),‘Hydralazine’ and ‘Methyldopa’(n=4, respectively), ‘Hydralazine’(n=9), ‘Nifedipine’(n=56), respectively. [Conclusion] We found that prescription of drugs among pregnant women should be evaluated regardless of the presence or absence of the diagnosis as hypertension during pregnancy when we examine the prescription of antihypertensive drugs to pregnant women based on claims data. Less
|
-
-
[Presentation] Taku Obara, Manabu Akazawa, Takayoshi Ohkubo, Mami Ishikuro, Hirohito Metoki, Aiko Shono, Hidekazu Nishigori, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama2012
Author(s)
Taku Obara, Manabu Akazawa, Takayoshi Ohkubo, Mami Ishikuro, Hirohito Metoki, Aiko Shono, Hidekazu Nishigori, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama
Organizer
28th International Conference on Pharmacoepidemiology & Therapeutic Risk Management
Place of Presentation
Spain, Barcelona
Year and Date
2012-08-26
-
