2012 Fiscal Year Final Research Report
Identification of cardiac reprogramming factors by heterokaryon-based genes expression analysis
| Project/Area Number |
23659419
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
OH Hidemasa 岡山大学, 岡山大学病院, 教授 (50372579)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 心臓内幹細胞 / 直接再プログラム化 / 心筋細胞 / 転写因子 |
|---|
| Research Abstract |
We employed a heterokaryon-based gene screening approach to identify the crucial transcription factors might be involved in direct cardiac reprogramming. By using this novel technique, we found a series of transcription factors essential for right and left ventricular formation include GATA4, Mef2c, Tbx5, Myocardin, and Hand2 were capable of converting the cardiac progenitor cells toward mature cardiomyocytes directly in vitro.
|
-
[Journal Article] Molecular Genetic and Functional Characterization Implicate Muscle-Restricted Coiled-Coil Gene (MURC) as a Causal Gene for Familial Dilated Cardiomyopathy2011
Author(s)
Rodriguez G, Ueyama T, Ogata T, Czernuszewicz G, Tan Y, Dorn GW 2nd, Bogaev R, Amano K, Oh H, Matsubara H, Willerson JT, Marian AJ.
-
Journal Title
Circ Cardiovasc Genet
Volume: 4(4)
Pages: 394-358
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
