2012 Fiscal Year Final Research Report
Cancer stem cells and cancer microenvironment in thyroid cancer
| Project/Area Number |
23659478
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAYAMA Yuji 長崎大学, 医歯薬学総合研究科, 教授 (30274632)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 甲状腺癌 / 癌幹細胞 / 微小環境 |
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| Research Abstract |
Epithelial-to-mesenchymal transition (EMT) has been thought to play a critical role in invasion and metastasis of cancer and to be associated with cancer stem cell (CSC) properties. The most reliable marker for thyroid CSCs so far identified appears to be aldehyde dehydrogenase (ALDH). Our results show that EMT seems to be associated with CSC properties in ALDH-negative human thyroid cancer cells.
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