2012 Fiscal Year Final Research Report
Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis
| Project/Area Number |
23659546
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | TSLP / アトピー性皮膚炎 / 小胞体ストレス応答 / フィラグリン |
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| Research Abstract |
Thymic stromal lymphopoietin (TSLP) is one of the most important chemokine for pathogenesis of atopic dermatitis (AD), which is secreted by keratinocytes. However, which kinds of stimuli induce TSLP is not unidentified well. In this study, we suggested the unfolded protein response in keratinocytes induce TSLP.
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[Journal Article] Consequences of two different amino acid substitutions at the same codon in KRT14indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis2011
Author(s)
Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DAD, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H
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Journal Title
J Invest Dermatol
Volume: 131
Pages: 1869-1876
Peer Reviewed
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