2012 Fiscal Year Final Research Report
Study on volatile organic compounds associated with schizophrenia.
| Project/Area Number |
23659572
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2011) |
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Principal Investigator |
ITOKAWA Masanari 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 参事研究員 (40332324)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 精神薬理学 |
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| Research Abstract |
We found a case with schizophrenia who is in pedigree with multiple affected individuals and had a frameshift mutation reducing enzymatic activity by 50% in glyoxalase1 gene. The case suggested possibility of carbonyl stress is involved in pathophysiology of schizophrenia and high plasma AGEs was detected in 46.7% of the patients. We studied on volatile organic compounds associated with schizophrenia to reveal pathophysiology of the disease(Arai et al. Arch Gen Psychiatry 2010). We detected volatile organic compounds contained in the air of the ward by using GCMS
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Research Products
(11 results)
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[Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia2012
Author(s)
Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(1)
Pages: 30-7
Peer Reviewed
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[Journal Article] Positive association of Phencyclidine-responsive genes, PDE4A and PLAT,with schizophrenia2011
Author(s)
Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada at, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 156(7)
Pages: 850-858
Peer Reviewed
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[Journal Article] Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis2011
Author(s)
Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
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Journal Title
Curr Neuropharmacol
Volume: 9(1)
Pages: 137-142
Peer Reviewed
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[Journal Article] Classification of First-Episode Schizophrenia Patients and Healthy Subjects by Automated MRI Measures of Regional Brain Volume and Cortical Thickness2011
Author(s)
Takayanagi Y, Takahashi T, Orikabe L, Mozue Y, Kawasaki Y, Nakamura K, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Suzuki M
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Journal Title
PLoS One
Volume: 6(6)
Pages: e21047
Peer Reviewed
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