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2011 Fiscal Year Final Research Report

Development of the multiresonance magnetic resonance imaging technique

Research Project

  • PDF
Project/Area Number 23659586
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

TOCHIO Hidehito  京都大学, 大学院・工学研究科, 准教授 (70336593)

Project Period (FY) 2011
KeywordsMRI / NMR / 多重共鳴NMR
Research Abstract

Multiple-resonance NMR is routinely employed in structure analysis of proteins. In this study, application of the multiple-resonance principle to Magnetic Resonance Imaging(MRI) was examined. As a result, triple-resonance MRI has been demonstrated to be feasible at least on aqueous solution sample. In addition, a series of 13C polymers have been shown to be an excellent molecular probe for 1H-{13C} double resonance MRI in tumor-bearing mice.

  • Research Products

    (6 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Substrate/Product-targeted NMR monitoring of pyrimidine catabolism and its inhibition by a clinical drug2012

    • Author(s)
      Yamada H, Mizusawa K, Igarashi R, Tochio H, Shirakawa M, Tabata Y, Kimura Y, Kondo T, Aoyama Y, Sando S
    • Journal Title

      ACS Chem Biol

      Volume: 7巻 Pages: 535-42

    • Peer Reviewed
  • [Journal Article] 磁気共鳴を使った真核細胞内タンパク質の構造・機能解析2012

    • Author(s)
      杤尾豪人、白川昌宏
    • Journal Title

      薬学雑誌

      Volume: 132巻 Pages: 185-193

  • [Journal Article] NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap802012

    • Author(s)
      Sekiyama N, Jee J, Isogai S, Akagi K, Huang TH, Ariyoshi M, Tochio H, Shirakawa M
    • Journal Title

      J Biomol NMR

      Volume: 52巻 Pages: 339-350

    • Peer Reviewed
  • [Presentation] Analysis of proteins inside human cultured cells by NMR2011

    • Author(s)
      杤尾豪人
    • Organizer
      The 4th Asia Pacific NMR symposium
    • Place of Presentation
      Beijing、中国
    • Year and Date
      20111016-18
  • [Presentation] Magnetic resonance methods for analyses of structure and dynamics of intracellular proteins and cells2011

    • Author(s)
      杤尾豪人
    • Organizer
      第49回生物物理学会年会
    • Place of Presentation
      姫路
    • Year and Date
      20110916-18
  • [Book] 「蛍光イメージング/MRIプローブの開発」第12章核磁気共鳴を利用した生体計測2011

    • Author(s)
      杤尾豪人、白川昌宏
    • Total Pages
      104-113
    • Publisher
      シーエムシー出版

URL: 

Published: 2013-07-31  

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