2011 Fiscal Year Final Research Report
Patho-physiology of the radiation necrosis in the brain
| Project/Area Number |
23659596
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NONOGUCHI Naosuke 大阪医科大学, 医学部, 助教 (70388263)
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| Project Period (FY) |
2011
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| Keywords | 脳放射線壊死 / 血管新生 / 炎症 / アストロサイト / マクロファージ / VEGF / HIF-1α |
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| Research Abstract |
Radiation necrosis in the brain became a serious problem after high-dose irradiation for malignant brain tumors. We analyzed the surgically removed specimen of symptomatic radiation necrosis of the human patients, by H & E staining and immunohistochemistry. From the analysis, it is revealed that fragile and leaky angiogenesis and inflammation were the major cause of peri-lesional edema in the radiation necrosis.
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