2012 Fiscal Year Final Research Report
Serological immunotherapy against intra-cellular tumor antigens -combination with chemotherapy-
| Project/Area Number |
23659649
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
DOKI Yuichiro 大阪大学, 医学系研究科, 教授 (20291445)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Hiroshi 大阪大学, 医学系研究科, 助教 (80362713)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒト抗体 / 化学療法併用 / NY -ESO-1 / Fc 受容体 |
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| Research Abstract |
We established the mouse model of serological immunotherapy combined with chemotherapy. NY -ESO-1 Ab E978 was administered i.v. to mice bearing NY -ESO-1-expressing CT26 tumor and treated with 5-FU. NY -ESO-1-Ag-Ab complex was observed in these mice and the anti-tumor effect was dependent on Fc portion and antigen presenting cells as dendritic cells, followed by induction and activation of antigen specific CD8 T cells, resulting in anti-tumor response.
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