2012 Fiscal Year Final Research Report
Development oftherapy for acute traumatic brain injury
| Project/Area Number |
23659687
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
LIU Keyue 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40432637)
WAKE Hidenori 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60570520)
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| Research Collaborator |
OKUMA Yu 岡山大学, 大学院・医歯薬学総合研究科, 博士課程院生
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脳外傷 / 血液-脳関門 / HMGB1 / 脳浮腫 / 抗体医薬 |
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| Research Abstract |
High mobility group box-1 （HMGB1 ）has been paid much attention as an important damage-associated molecular pattern. I established anti-HMGB1 antibody therapy for ischemic brain injury and brain vasospasm. In the present study, I examined whether anti-HMGB1 antibody therapy may exert beneficial effects on traumatic brain injury in rats. The results showed that HMGB1 in neurons at injured site was translocated and released into extracellular space. The administration of anti-HMGB1 antibody inhibited the disruption of blood-brain barrier and resulting brain edema. Anti-HMGB1 antibody therapy will be beneficial for the treatment of traumatic brain injury.
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[Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain2012
Author(s)
Shichita T, Hasegawa E, Kim ura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi HK, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K & Yoshimura A.
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Journal Title
Nature Med
Volume: 18(6)
Pages: 911-7
DOI
Peer Reviewed
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[Journal Article] Anti-high mobility group box-1 antibody therapy for traumatic brain injury2012
Author(s)
Okuma Y, Liu K, Wake H, Zhang J, Maruo T, Date I, Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, Yamamoto Y, Yamamoto H, Takahashi HK, Mori S, Nishibori M.
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Journal Title
Ann Neurol
Volume: 72(3)
Pages: 373-84
DOI
Peer Reviewed
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