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2013 Fiscal Year Final Research Report

Development of novel treatment against malignant transformation of astrocytoma

Research Project

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Project/Area Number 23659694
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionNagoya City University

Principal Investigator

TANIKAWA Motoki  名古屋市立大学, 医学(系)研究科(研究院), 講師 (20343402)

Project Period (FY) 2011 – 2013
Keywordsastrocytoma / chemotherapy / p53
Research Abstract

We tried to confirm effects of compounds, which arrest cell cycle though p53-independent pathway, against the malignant transformation of ethylnitrosourea induced glioma by identifying WHO grade and measuring MIB-1 labeling index. Although totally 20 compounds were examined for these term, there was no compound, which showed significant effect comparing with control compound. On the other hand, we achieved analyses for the repellent in glioma cell invasion by using 3-dimensional glioma cell invasion model in collagen gel. The production of repellent was considered to be affected by oxygen supply. Furthermore, the effect of repellent might continue unless physicochemical modulation of circumference environment occurred.

  • Research Products

    (1 results)

All 2012

All Presentation (1 results)

  • [Presentation] in vitro におけるラットグリオーマ細胞株C6周辺浸潤能の評価2012

    • Author(s)
      坂田知宏、谷川元紀、山田和雄
    • Organizer
      日本脳神経外科学会第72回学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      20121016-18

URL: 

Published: 2015-06-25  

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