2014 Fiscal Year Final Research Report
A single blind randomized trial about efficacy of the remote ischemic preconditioning for the development of deep vein thrombosis during total knee arthroplasty using the tourniquet.
| Project/Area Number |
23659737
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 遠隔虚血プレコンディショニング / 可溶性フィブリンモノマー複合体 / NFκ-B / IL-6 / IL-10 / 虚血再潅流障害 / 全人工膝関節形成術 |
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| Outline of Final Research Achievements |
We have studied effects of remote ischemic preconditioning (RIPC) on the development of deep vein thrombosis and inflammatory reaction during total knee arthroplasty using the tourniquet prospectively.
RIPC (four five-minute cycles of occlusion and reperfusion in the upper limb) resulted in significantly decreased the soluble fibrin monomer complex levels after 20 minutes following tourniquet deflation. Our findings suggest that RIPC have an inhibitory effect for thrombus formation immediately after surgery at least in the short term. Moreover, we observed that the reduction of NFκ-B activity and IL-6 production and that increased production of anti-inflammatory cytokine IL-10 in the RIPC group. Our data suggest that RIPC attenuate activation of NFκ-B and then modulate the inflammatory response.
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| Free Research Field |
医歯薬学 外科系臨床医学 麻酔科学 周術期管理学
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