2012 Fiscal Year Final Research Report
Effect of highsalt intake onpenile corpus cavernosum
| Project/Area Number |
23659760
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KISHIMOTO Tomoteru 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 非常勤講師 (40398003)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Masayuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50325255)
YAMAGUCHI Kinihisa 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90464346)
KIMURA Kazunori 名古屋市立大学, 大学院・医学研究科, 教授 (00423848)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食塩過剰摂取 / 勃起不全 / MR / 食塩感受性 |
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| Research Abstract |
We investigated whether salt excess itself induces erectile dysfunction (ED) independent of hypertension in Dahl salt-sensitive (Dahl-S) hypertensive rats. In Dahl-S hypertensive rats, MR antagonism without antihypertensive effect had protective effects against ED. Salt excess induced ED independently of hypertension. Salt excess may directly injure penile tissue through MR activation.
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