Diagnostic method by identifying specific T cell clone in Vogt-Koyanagi-Harada disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 23659803
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Asahikawa Medical College
• Principal Investigator: KINOUCHI Reiko 旭川医科大学, 医学部, 特任准教授 (70344562)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: フォークト・小柳・原田病 / T細胞受容体

Outline of Final Research Achievements

We tried to identify specific T cell clone for Vogt-Koyanagi-Harada disease to establish diagnostic method. We found a clone which was seen in peripheral blood of 13 out of 17 VKH cases, while the clone was not seen in uveitis other than VKH and VKH after treatment. Though we performed qPCR detecting this clone to establish diagnostic methods, we could not detect the clone in VKH which developed after 2011. (We reported this results in the 119th annual meeting of the Japanese Ophthalmological Society, 2015.)

Free Research Field

眼科