2012 Fiscal Year Final Research Report
Personal Made Immuno-therapy for Uveitis Using Regulatory T Cells
| Project/Area Number |
23659807
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MOCHIZUKI Manabu 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10010464)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Sunao 理化学研究所, 網膜再生医療研究チーム, 研究員 (10299456)
TAKASE Hiroshi 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (20451940)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 眼免疫 |
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| Research Abstract |
Regulatory T cells (Treg) induced by retinal pigment epithelial cells strongly suppressed proliferation of active T cells and production of inflammatory cytokines by T cells. Furthermore, removing non-suppressive fraction of Treg exhibited much more intense suppressive activities. The suppressive fraction of Treg was capable of suppressing experimental autoimmune uveitis in mice. In human, Treg and suppressive fraction of Treg were induced similarly, but using pre-stimulation by TGF-b.These results indicate that Treg (or suppressive fraction of Treg) can be used for the treatment of non-infectious uveitis in human.
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