2013 Fiscal Year Final Research Report

Cell cycle atlas of periodontium

Research Project

Project/Area Number	23659977
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Periodontal dentistry
Research Institution	Okayama University
Principal Investigator	YAMAMOTO Tadashi 岡山大学, 大学病院, 講師 (50432662)
Co-Investigator(Kenkyū-buntansha)	TAKASHIBA Shogo 岡山大学, 大学院医歯薬学総合研究科, 教授 (50226768) HATANAKA Kazu 岡山大学, 大学院医歯薬学総合研究科, 助教 (50362992) YAMASHIRO Keisuke 岡山大学, 大学院医歯薬学総合研究科, 助教 (30581087) YAMAGUCHI Tomoko 岡山大学, 大学院医歯薬学総合研究科, 助教 (90580267)
Project Period (FY)	2011 – 2013
Keywords	細胞周期 / 細胞増殖・分化 / 歯周組織
Research Abstract	Fucci transgenic mice constitutively expressing cell-cycle probes are important tools to analyze the spatiotemporal transition of the cell-cycles in periodontium, especially, are useful to visualize the cell-cycles of undifferentiated mesenchymal cells and gingival epithelial cells. The molecular imaging employing Fucci technology demonstrated that a series of active enzymes produced by neutrophil during periodontal inflammation would induce G1-arrest of the cell-cycle of periodontal cells.