2012 Fiscal Year Final Research Report
Amygdala functional network underlying fear extinction
| Project/Area Number |
23700367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NOMURA Hiroshi 東京大学, 大学院・薬学系研究科, 助教 (10549603)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 記憶 / 扁桃体 / 恐怖条件づけ |
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| Research Abstract |
In this study, we used contextual fear conditioning, large-scale imaging with immediate early genes and whole-cell recordings to demonstrate the neuronal circuits underlying fear extinction and reinstatement and found the results described below.(1) The neuronal activity in the infralimbic cortex is decreased during fear reinstatement.(2) Neural plasticity in the infralimbic cortex is involved in fear reinstatement.(3) Excitatory synaptic currents onto infralimbic cortical neurons are reduced with fear reinstatement.(4) A specific subset of basolateral amygdala neurons is active during fear memory expression.(5) The basolateral amygdala neurons that are active during fear memory expression have different projection from the other neurons.Further analysis of our identified neuronal circuits will contribute to understanding the cellular mechanisms underlying fear extinction and reinstatement.
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[Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.2011
Author(s)
Yusuke Sekine, Shuichi Takagahara, Ryo Hatanaka, Takeshi Watanabe, Haruka Oguchi, Takuya Noguchi, Isao Naguro, Kazuto Kobayashi, Makoto Tsunoda, Takashi Funatsu, Hiroshi Nomura, Takeshi Toyoda, Norio Matsuki, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda and Hidenori Ichijo
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Journal Title
Journal of Cell Science
Volume: 124(Pt 17)
Pages: 3006-3016
DOI
Peer Reviewed
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