2012 Fiscal Year Final Research Report
Evaluation and functionalization of Tetra-PEG gels as medical structural materials
| Project/Area Number |
23700555
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAKAI Takamasa 東京大学, 大学院・工学系研究科, 助教 (70456151)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ハイドロゲル / Tetra-PEG ゲル / 医用構造材料 / 生分解性 |
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| Research Abstract |
In order to apply Tetra-PEG gel for biomedical structural materials, we evaluated the biocompativility and drug releasing behavior, and introduced the biodegradability to Tetra-PEG gel. We confirmed the biocompatibility of raw material, gelation reaction, and formed gels. We investigated the release of model drugs from Tetra-PEG gels, and clarified the effect of mesh size on the drug releasing behavior. We designed the novel molecules and succeeded in the fabrication of biodegradable Tetra-PEG gels.
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[Journal Article] Development and evaluation of tetrapod-shaped granular artificial bones2012
Author(s)
S. Choi, I. Liu, K. Yamamoto, K. Igawa, M.Mochizuki, T. Sakai, E. Ryosuke, M. Honnami, S. Suzuki, U. Chung, N. Sasaki
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Journal Title
Acta Biomaterialia
Volume: 8
Pages: 2340-2347
DOI
Peer Reviewed
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