2014 Fiscal Year Final Research Report
Studies on the relationships between diabetes mellitus and dementia by measurement of brain neurotransmitter
| Project/Area Number |
23700942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 糖尿病 / 認知症 / マイクロダイアリシス / セロトニン / 一酸化窒素 / スコポラミン |
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| Outline of Final Research Achievements |
In this study, we have investigated the relationships between diabetes and dementia by measuring the levels of serotonin (5-HT) and the nitric oxide (NO) from the diabetic hippocampus of rat injected scopolamine which is often used to produce temporal dementia. In addition, we studied the effects of dementia on the locomotor activity, elevated plus-maze, Y’s maze, and the intakes of food and water in diabetic rats and mice. As a result, it is suggested that the diabetes with the condition of dementia led to the aggravation of memory. However, no change occurred the 5-HT level and NO level of the hippocampus. The 5-HT3 and 5-HT4 receptors are, at least, unlikely to be associated with diabetes and scopolamine-induced dementia.
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| Free Research Field |
栄養生理学
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