2012 Fiscal Year Final Research Report
Elucidation of the mechanism of cancer cell invasion through a novel actin cytoskeleton-associated protein TAB182
| Project/Area Number |
23701068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
OHISHI Tomokazu 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 研究員 (50442546)
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| Project Period (FY) |
2011 – 2012
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| Keywords | アクチン細胞骨格 / 細胞運動 / ポリ(ADP-リボシル)化 |
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| Research Abstract |
A novel tankyrase-binding protein TAB182, which we have found and named, localizes to the cytoplasm where it co-stains with the cortical actin network. However, its functional significance remains unknown. In this study, we found that TAB182 colocalizes with F-actin and is involved in the regulation of cell migration and invasion through the reorganization of actin cytoskeleton
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