2013 Fiscal Year Final Research Report
Therapeutic strategy for gastric cancer using apoptosis activating small molecule
| Project/Area Number |
23701101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Saga University |
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Principal Investigator |
IDE Takao 佐賀大学, 医学部, 助教 (40587549)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 小分子化合物 / アポトーシス |
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| Research Abstract |
Peritoneal dissemination from gastric cancer is lethal disease, therefore understanding such molecular mechanism and establishment of new therapeutic strategy is essential. PPLGM, a small molecule which we discovered,has anti-tumor effect in gastric cancer cells through activating apoptosis pathway. Our study suggested the possibility that PPLGM is one of key drug for gastric cancer.
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Research Products
(16 results)
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[Journal Article] Primary squamous cell carcinoma of the liver concomitant with primary colon cancer : report of a case2013
Author(s)
Kiyoto Morito,Keita Kai,Atsushi Miyoshi,Hiroshi Kubo,Takao ide,Shinya Azama,Hiroyuki Irie,Yasuo Koga,Kenji Sumi,Osamu Ikeda,Kenji Kitahara,Hirokazu Noshiro
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Journal Title
Clinical Journal of Gastroenterology
Volume: 62
Pages: 134-138
Peer Reviewed
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[Journal Article] Selective killing of cancer cells by a small molecule targeting the stress response to ROS2011
Author(s)
Raj L, ide T, Gurkar AU, Foley M, Schenone M, Li X, Tolliday NJ, Golub TR, Carr SA, Shamji AF, Stern AM, Mandinova A, Schreiber SL, Lee SW
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Journal Title
Nature
Volume: Jul 13;475(7355)
Pages: 231-4
Peer Reviewed
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