2013 Fiscal Year Final Research Report
Research of transcriptional repression mechanism by histone acetylation in the maintenance of cell fate
| Project/Area Number |
23770257
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kwansei Gakuin University |
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Principal Investigator |
SHIBATA Yukimasa 関西学院大学, 理工学研究科, 博士研究員 (80314053)
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| Project Period (FY) |
2011 – 2013
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| Keywords | クロマチン / BET / 細胞運命維持 / UTX / H2A.z |
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| Research Abstract |
Histone acetylation is required for the maintenance of cell fates. But, its molecular mechanism is largely unknown. In this study, we investigate the dynamics of chromatin status that regulate cell-fate maintenance. As a results, we found that acetylated histone recruit histone variant HTZ-1/H2A.z on the loci that encodes transcription factor, and repress the locus. The recruitment of HTZ-1 is inhibited by H3K27me. We also found that the CeBAF complex that control histone deposition is required for the maintenance of cell fates.
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[Journal Article] The Novel Secreted Factor MIG-18 Acts with MIG-17/ADAMTS To Control Cell Migration in Caenorhabditis elegans2014
Author(s)
Hon-Song Kim, Yuko Kitano, Masataka Mori, Tomomi Takano, Thomas Edward Harbaugh, Kae Mizutani, Haruka Yanagimoto, Sayaka Miwa, Shinji Ihara, Yukihiko Kubota, Yukimasa Shibata, Kohji Ikenishi, Gian Garriga, and Kiyoji Nishiwaki
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Journal Title
Genetics
Volume: 196巻
Pages: 471-479
DOI
Peer Reviewed
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