2012 Fiscal Year Final Research Report
Novel Role of mitotic cell rounding in epithelial invagination
| Project/Area Number |
23770264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KONDO Takefumi 独立行政法人理化学研究所, 形態形成シグナル研究グループ, 基礎科学特別研究員 (60565084)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 上皮形態形成 / 細胞分裂 / 分裂期球形化 / ショウジョウバエ |
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| Research Abstract |
Animal cells change their shape into sphere upon mitotic entry. In this study, we revealed a novel active role of mitotic cell rounding in epithelial invagination of the Drosophila tracheal placode. Mitotic rounding, but not cell division, of the central cells in the placode is required to accelerate invagination, in conjunction with centripetal pressure from the surrounding cells. These results indicate that mitotic rounding regulates the epithelial tissue morphogenesis independent of its role in cell division.
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