2012 Fiscal Year Final Research Report
Chemical biological study of proanthocyanidins to elucidate the functionalities for human health
| Project/Area Number |
23780123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Osaka Electro-Communication University |
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Principal Investigator |
SAITH Akiko 大阪電気通信大学, 工学部, 准教授 (40415162)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生物活性物質 / 化学生物学 |
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| Research Abstract |
Proanthocyanidins (PAs), which have various strong biological activities, were modified with fluorescent molecules, fluorous tags, etc. by using our regioselective deprotection method for chemical biological studies of PAs. Using fluorous tags, the interaction between PAs and recombinant DNA polymerase ? was detected with SDS page. Furthermore, we identified that 3,3’’-digallate dimers showed extremely high activity against decrease in cell proliferation (HeLa S3). However, the effect of oligosaccharides for stabilization of PAs was not detected with antioxidant activity.
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[Presentation]2012
Author(s)
岡本泰輔、齊藤安貴子
Organizer
第54回天然有機化合物討論会
Place of Presentation
東京
Year and Date
2012-09-18
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