2012 Fiscal Year Final Research Report
Syntheses of novel amino acids and natural product derived from amino acid by using memory of chirality
| Project/Area Number |
23790010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 合成化学 |
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| Research Abstract |
Development of asymmetric intra- and intermolecular conjugate addition reaction via C-N axially chiral enolate intermediates were achieved. Multisubstituted β-lactams were prepared by using asymmetric intramolecular conjugate addition reaction. β-Lactams were converted into novel hybrid amino acid derivatives consisting of aspartic acid-glutamic acid. On the other hand, total synthesis of manzacidin A was completed by using intermolecular conjugate addition reaction.
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[Journal Article] Protonation-Assisted Conjugate Addition of Enolate: Asymmetric Synthesis of Multisubstituted-β-Lactams from α-Amino Acids via Memory of Chiralty2012
Author(s)
Yoshimura, T.; Takuwa, M.; Tomohara, K.; Uyama, M.; Hayashi, K.; Yang, P.; Hyakutake, R.; Sasamori, Y.; Tokitoh, N.; Kawabata, T
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Journal Title
Chem, E. J
Volume: 18
Pages: 15330-15336
DOI
Peer Reviewed
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