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2012 Fiscal Year Final Research Report

Development of Novel Chip for Isolation of Circulating Tumor Cells Using Size-Selection and Photochemical Reaction

Research Project

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Project/Area Number 23790023
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionTokyo University of Science

Principal Investigator

ARIYASU Shinya  東京理科大学, 総合研究機構, ポストドクトラル研究員 (50586998)

Project Period (FY) 2011 – 2012
Keywords光切断リンカー / 血中循環癌細胞
Research Abstract

The isolation of circulating tumor cells (CTCs) is expected toearly-diagnosis and tailor-made care of cancer. However, although the detection of CTCs was reported, the collection of living CTCs have been not realized. In this project, we developed microfluidic device composed of size-selection andIgG-coated photoreactive silicon device. This photoreactive IgG-coated silicon device can capture the target cells from cell-mixture and collect the living target cells by photoirradiation.

  • Research Products

    (17 results)

All 2012 2011 2010 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (9 results)

  • [Journal Article] The Selective Capture and Collection of Live Target Cells Using a Silicon Wafer Device Modified with Antibodies via a Photocleavable Linker2012

    • Author(s)
      S. Ariyasu, K. Hanaya, E. Watanabe, T. Suzuki, K. Horie, M. Hayase, R. Abe, S. Aoki
    • Journal Title

      Langmuir

      Volume: 28巻 Pages: 13118-13126

    • Peer Reviewed
  • [Journal Article] Photochemical Cleavage Reaction of 8-Quinolinyl Sulfonates That Are Halogenated and Nitrated at the 7-Position2011

    • Author(s)
      S. Ariyasu, K. Hanaya, M. Tsunoda, M. Kitamura, M. Hayase, R. Abe, S. Aoki
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 59巻 Pages: 1355-1362

    • Peer Reviewed
  • [Journal Article] Affinity Clusters: An Adenine-Coated Gold Cluster Binds to Thymine Loops in DNA2011

    • Author(s)
      T. Yamamura, S. Ariyasu, R. Sakamoto
    • Journal Title

      Chemistry an Asian Journal

      Volume: 6巻 Pages: 1761-1765

    • Peer Reviewed
  • [Journal Article] Inorganic Bioconjugates of Gold Clusters and Nanoparticles -Briefly History and Recent Development-2010

    • Author(s)
      T. Yamamura, S. Ariyasu
    • Journal Title

      Bulletin of Japan Coordination Chemistry

      Volume: 55巻 Pages: 71-77

    • Peer Reviewed
  • [Journal Article] Alignment of Gold Clusters on DNA via a DNA-recognizing Zinc Finger-Metallothionein Fusion Protein2009

    • Author(s)
      S. Ariyasu, A. Onoda, R. Sakamoto, T. Yamamura
    • Journal Title

      Bioconjugate Chemistry

      Volume: 20巻 Pages: 2278-2285

    • Peer Reviewed
  • [Journal Article] Conjugation of Au11 Cluster with Cys-rich Peptides Containing the α-Domain of Metallothionein2009

    • Author(s)
      S. Ariyasu, A. Onoda, R. Sakamoto, T. Yamamura
    • Journal Title

      Dalton Transactions

      Pages: 3742-3747

    • Peer Reviewed
  • [Journal Article] Circular Dichroism of Neutral Zinc Porphyrin-Oligonucleotide Conjugates Modified with Flexible Linker2009

    • Author(s)
      A. Onoda, M. Igarashi, S. Naganawa, K. Sasaki, S. Ariyasu, T. Yamamura
    • Journal Title

      Bulletin of the Chemical Society Japan

      Volume: 82巻 Pages: 1280-1286

    • Peer Reviewed
  • [Journal Article] Minimal motif peptide structure of metzincin clan zinc peptidases in micelles2009

    • Author(s)
      A. Onoda, T. Suzuki, H. Ishizuka, R. Sugiyama, S. Ariyasu, T. Yamamura
    • Journal Title

      Journal of Peptide Science

      Volume: 15巻 Pages: 832-841

    • Peer Reviewed
  • [Presentation] The Selective Capture and Collection of Live Target Cells Using a Photoreactive Silicon Wafer Device Modified with Antibodies via Photocleavable Linkers2012

    • Author(s)
      S. Ariyasu, K. Hanaya, E. Watanabe, M. Hoshi, T. Suzuki, K. Horie, M. Hayase, R. Abe, S. Aoki
    • Organizer
      13thTetrahedron Symposium Asia Edition (ポスター)
    • Place of Presentation
      中国台湾台北市
    • Year and Date
      20121100
  • [Presentation] 光分解可能なケミカルリンカーを用いた目的細胞の選択的捕捉、回収用デバイスの開発(ポスター)2012

    • Author(s)
      有安真也、花屋賢悟、渡邉瑛太、星美里、鈴木利宙、堀江和峰、早瀬仁則、安部良、青木伸
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      20121100
  • [Presentation] 光分解性リンカーを介した抗体修飾デバイスによる目的細胞の選択的捕捉と回収(口頭)2012

    • Author(s)
      有安真也、花屋賢悟、渡邉瑛太、星美里、鈴木利宙、堀江和峰、早瀬仁則、安部良、青木伸
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      20120900
  • [Presentation] Development of the Specific Antibodies-Coating Photoreactive Silicon Devices for Efficient Detection and Collection of Target Cell (口頭)2011

    • Author(s)
      S. Ariyasu, K. Hanaya, M. Hoshi, E. Watanabe, T. Suzuki, M. Hayase, R. Abe, S. Aoki
    • Organizer
      8th AFMC International Medicinal and Chemical Symposium (AIMECS11)
    • Place of Presentation
      東京都
    • Year and Date
      20111100
  • [Presentation] Alignment of Gold Clusters on DNA via a Zinc Finger-Metallothionein Fusion Protein (ポスター)2010

    • Author(s)
      S. Ariyasu, T. Yamamura, S. Aoki
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies (PACICHEM2010)
    • Place of Presentation
      アメリカハワイ州
    • Year and Date
      20101200
  • [Presentation] Location of a gold cluster at the desired position of DNA via a zinc finger-metallothionein conjugate (口頭、招待講演)2009

    • Author(s)
      S. Airyasu, R. Sakamoto, T. Yamamura
    • Organizer
      2ndInternational Symposium on Bioinorganic Chemistry of the New Era
    • Place of Presentation
      岐阜県
    • Year and Date
      20090800
  • [Presentation] Conjugation of Au11 Cluster with Cys-rich Peptides Containing the α-Domain of Metallothionein (ポスター)2009

    • Author(s)
      S. Ariyasu, A. Onoda, R. Sakamoto, T. Yamamura
    • Organizer
      International Conference on Biological Inorganic Chemistry 2009
    • Place of Presentation
      愛知県
    • Year and Date
      20090700
  • [Presentation] Location of a gold cluster at the desired position of DNA via a zinc finger-metallothionein conjugate (ポスター)2008

    • Author(s)
      S. Ariyasu, R. Sakamoto, T. Yamamura
    • Organizer
      International Union of Materials Research Societies-International Conference in Asia 2008
    • Place of Presentation
      愛知県
    • Year and Date
      20081200
  • [Presentation] ジンクフィンガー・メタロチオネイン融合蛋白質を用いたAu クラスターのDNA 上への配列(口頭、招待講演)2007

    • Author(s)
      有安真也
    • Organizer
      錯体化学若手の会勉強会
    • Place of Presentation
      東京都
    • Year and Date
      20071200

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Published: 2014-09-25  

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