2013 Fiscal Year Final Research Report

Examination of reaction products the lipid radical and biomolecule.

Research Project

Project/Area Number	23790053
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Physical pharmacy
Research Institution	Nihon Pharmaceutical University
Principal Investigator	TAKAJO Tokuko 日本薬科大学, 薬学部, 講師 (80424068)
Project Period (FY)	2011 – 2013
Keywords	脂質過酸化 / 酵素反応 / 非酵素反応
Research Abstract	In lipid peroxidation reaction,it is measured without distinguishing these reaction products, which oxidative stress caused by reactive oxygen species or radicals reaction products and the biological enzymatic reaction products. Therefore, it is considered to be important for oxidative stress prevention by an antioxidant agent to distinguish these reaction products. I investigated whether there are differences in the reaction products produced by the reaction with biomolecular substances and enzymatic reaction by lipoxygenase, a chemical reaction by the radical generator, the physical reaction by UV irradiation. As a result, the reaction intermediates generated in the physical reaction and enzymatic reactions and chemical reactions, no difference was observed in the reaction product.