2013 Fiscal Year Final Research Report
Transcription of TSPO gene under the brain inflammation
| Project/Area Number |
23790314
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
TSUYOSHI Tahara 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (20419708)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | トランスローケータープロテイン / 炎症 / 転写 |
|---|
| Research Abstract |
Since it is known that, during inflammation, TSPO proteins are induced in the inflammation region and TSPO plays a role as an indicator of inflammation, especially within a brain. However, there are many unknown about the induction mechanisms of TSPO gene expression during inflammation. Then, in order to clarify an inflammation-specific transcriptional cis element in TSPO gene, I carried out searching the inflammation responsive element in the upstream region of the mouse and the human TSPO gene.
In the about 1500 bp and 700 bp upstream of a mouse TSPO gene and human TSPO upstream, respectively, these regions could not response against inflammation stimulation such as LPS treatment.
As results, I could find no inflammation responsive element in the about 1500 bp and 700 bp upstream regions in the mouse and human TSPO gene, respectively.
|
