The comprehensive analysis of WNK, the causative gene of PHA2, andWNK signaling pathway

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790358
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SATO Atsushi 東京医科歯科大学, 難治疾患研究所, 助教 (30451925)
• Project Period (FY): 2011 – 2012
• Keywords: WNK / 偽性低アルドステロン症II型 / ショウジョウバエ(モデル生物)

Research Abstract

WNK1 and WNK4 have been linked to a hereditary form of human hypertension known as Pseudohypoaldosteronism type II (PHAII). We identified that the malfunction of this regulation caused PHAII in mouse. However, this misregulation cannot cause all of pathological conditions of PHAII, such as a mental retardation. We already identified Lhx8/Awh as a new downstream target of WNK signaling pathway. For studying the detail mechanism of WNK signaling pathway, we started to screen the interacting factor(s) using Drosophila melanogaster.

Research Products

• [Journal Article] WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression. (2013)
  • Author(s): Sato, A. and Shibuya, H.
  • Journal Title: PLoS One Volume: 8 Pages: e55301
  • DOI: doi:10.1371/journal.pone.0055301
  • Peer Reviewed
• [Journal Article] IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling. (2013)
  • Author(s): Goto, T., Sato, A. Shimizu, M., Adachi, S., Satoh, K., Iemura, S, Natsume, T and Shibuya, H.
  • Journal Title: PLoS One Volume: 8 Pages: e60865
  • DOI: doi:10.1371/journal.pone.0060865
  • Peer Reviewed
• [Journal Article] WNK4 is an essential effector of anterior formation in FGF signaling. (2013)
  • Author(s): Shimizu, M., Goto, T., Sato, A and Shibuya, H.
  • Journal Title: Genes to Cells Volume: (in press)
  • DOI: doi:10.1111/gtc.12048
  • Peer Reviewed
• [Presentation] AwhはWNKシグナル伝達経路の新規下流因子として機能する。 (2012)
  • Author(s): 佐藤淳
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-13
• [Presentation] A new downstram molecule, Awh is involved in the WNK signaling (2012)
  • Author(s): Atsushi Sato.
  • Organizer: Japanese Drosophila Research Conference 10
  • Place of Presentation: 新橋
  • Year and Date: 2012-10-15
• [Presentation] A new downstram molecule, Awh is involved in the WNK signaling (2011)
  • Author(s): Atsushi Sato.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13