2012 Fiscal Year Final Research Report
Functional roles of a novel glycosyltrasnferase BCGT1 in breast cancer cells
| Project/Area Number |
23790369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUO Taisuke 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (70533222)
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| Research Collaborator |
KATAGIRI Toyomasa 徳島大学, 疾患プロテオゲノム研究センター, 教授 (60291895)
ONO Masaya 国立がんセンター研究所, 化学療法部, 室 長 (00270900)
MIYOSHI Yasuo 兵庫医科大学, 医学部, 教授 (50283784)
BANDO Yoshimi 徳島大学, 病院, 准教授 (00238239)
SASA Mitsunori とくしまブレストケアクリニック
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖転移酵素 / 乳癌 |
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| Research Abstract |
In this study, we report the critical role of a novel glycosyltransferase BCGT1 which was frequently up-regulated in breast cancers cells. Knockdown of BCGT1 expression by siRNA significantly suppressedbreast cancer cell growth. We detected the commonly down-regulation of the several endoplasmic reticulum (ER) chaperons, which is important for cell survival and growth of cancer cells, at protein and mRNA levels in BCGT1-depleted cells. These alterations werecaused through the glycosylation of ER stress sensor IRE1 protein by BCGT1.These results indicate that BCGT1 regulates cell growth through glycosylation of IRE1.
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Research Products
(10 results)
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[Journal Article] Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis2013
Author(s)
Komatsu M, Yoshimaru T, Matsuo T, Kiyotani K, Miyoshi Y, Tanahashi T, Rokutan K, Yamaguchi R, Saito A, Imoto S, Miyano S, Nakamura Y, Sasa M, Shimada M, Katagiri T
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Journal Title
Int J Oncol
Volume: 42
Pages: 478-506
DOI
Peer Reviewed
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