2014 Fiscal Year Final Research Report
The significance of Caveolin-1 in experimental kidney disease
| Project/Area Number |
23790423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YAMAMOTO Izumi 東京慈恵会医科大学, 医学部, 助教 (60600468)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 実験腎炎 / カベオリン / Caveolin-1 |
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| Outline of Final Research Achievements |
To evaluate the significance of Caveolin-1 in kidney disease, we investigated several experimental kidney disease model using Caveolin-1 knockout, transgenic and wild type mouse.Ischemia reperfusion injury model, unilateral ureteral obstruction (UUO) model, eNOS inhibitor infusion model and anti-VEGF antibody infusion model were applied for this purpuse. We found that each model showed no remarkable change regarding Caveolin-1 expression and Caveolae formation on endothelial cells.Only UUO model and eNOS inhibitor infusion model showed increased tubulointerstitial fibrosis in Caveolin-1 knockout mouse compared with wild type mouse. Further examination revealed that only UUO model showed increased macrophage infiltration compared with wild type mouse.
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| Free Research Field |
腎移植
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