2013 Fiscal Year Final Research Report
The development of broad-spectrum antitumor agents with anti-HMGB1 antibody and clarification of its action mechanism
| Project/Area Number |
23790601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Okayama University |
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Principal Investigator |
WAKE HIDENORI 岡山大学, 医歯(薬)学総合研究科, 助教 (60570520)
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| Research Collaborator |
NISHIBORI Masahiro 岡山大学, 医歯薬学総合研究科, 教授 (50135943)
LIU Keyue 岡山大学, 医歯薬学総合研究科, 助教 (40432637)
TAKAHASHI Hideo 近畿大学, 医学部, 教授 (60335627)
MORI Shuji 就実大学, 薬学部, 教授 (50220009)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 薬物治療学 / 抗体医薬 / 抗腫瘍薬 / HMGB1 |
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| Research Abstract |
The osmotic pump continuous dosing of anti-HMGB1 antibody for 7 days significantly reduced tumor growth in mouse tumor graft model, whereas the same dose of anti-KLH antibody (control) had no effect on tumor growth. In the group treated with anti-HMGB1 antibody, the number of CD31-positive blood vessel in tumor tissue was significantly decreased in comparison with the number by treatment with anti-KLH antibody. However, the administration of anti-HMGB1 antibody had no effect on tumor growth in tumor graft model using immune-deficient mice. These data suggested that anti-HMGB1 antibody reduced tumor growth not directly but through immune response.
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Research Products
(11 results)
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[Presentation] Anti-HMGB1 Monoclonal Antibody Therapy for Traumatic Brain Injury in Rats2013
Author(s)
Nishibori M, Okuma Y, Liu K, Wake H, Maruo T, Teshigawara K, Yamamoto Y, Yamamoto H, Ohtsuka A, Yoshino T, Otani N, Tomura S, Shima K, Takahashi H, Date I, Mori S
Organizer
Merinoff World Congress 2013 : HMGB1
Place of Presentation
Feinstein Institute for Medical Research, New York, USA
Year and Date
2013-10-09
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[Presentation] Anti-high mobility group box-1 antibody therapy for traumatic brain injury2012
Author(s)
Okuma Y, Liu K, Wake H, Maruo T, Teshigawara K, Tomura S, Otani N, Shima K, Yamamoto Y, Yamamoto H, Takahashi H, Mori S, Date I, Nishibori M
Organizer
Neuroscience 2012
Place of Presentation
New Orleans Morial Convention Center, New Orleans, USA
Year and Date
2012-10-16
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