2013 Fiscal Year Final Research Report
The roles of glycolipids in nociception and analgesia.
| Project/Area Number |
23790647
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kitasato University (2013)
Tohoku Pharmaceutical University (2012)
Juntendo University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 疼痛 / ガングリオシド / 糖脂質 / スフィンゴ糖脂質 |
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| Research Abstract |
Gangliside GT1b produced nociceptive behavior and hyperalgesia in low-dose formalin tests. Antagonist studies and microdialysis in plantar tissues suggested that the subcutaneous glutamate levels and glutamate receptor activation play important roles in GT1b induced hyperalgesia. According to these results, we investigated weather GT1b produces heat/cold hyperalgesia, or mechanical allodynia. GT1b induced mechanical allodynia but not heat/cold hyperalgesia. In addition, GT1b increase glutamate levels in dorsal root ganglia neuron derived cell culture supernatants. Taken together, these findings suggest the hyperalgesic effects of GT1b is dependent on nociceptive stimuli and GT1b increase extracellular glutamate levels in cell cultures as well as subcutaneous tissues of mice.
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