2012 Fiscal Year Final Research Report

Liver toxicity caused by nanoparticle-rich or filtered diesel exhaust

Research Project

Project/Area Number	23790667
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene
Research Institution	Nagoya City University
Principal Investigator	ITO Yuki 名古屋市立大学, 大学院・医学研究科, 助教 (80452192)
Project Period (FY)	2011 – 2012
Keywords	ディーゼル排気ナノ粒子 / 肝臓 / 脂質 / 脂肪酸 / 粒子除去
Research Abstract	Diesel exhaust is a main airborne contaminant and includes many nanoparticles. Little studies reporting effects of nanoparticle-rich diesel exhaust (NR-DE) on liver have been conducted. In the present study, DNA microarray analysis showed that about 140 μg/m^3NR-DE for 1 month exposure caused the disruption of lipid homeostasis in rats. Additionally, exposure of NR-DE and filtered NR-DE, i.e. NR-DE without nanoparticles, increased hepatic fatty acids in mice. These results suggest that diesel exhaust induces the disturbance of lipid homeostasis and the main player exist in gas component in diesel exhaust.