2013 Fiscal Year Final Research Report
Adipocytokines and cardio-renal diseases
| Project/Area Number |
23790845
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
SHIBATA Rei 名古屋大学, 医学(系)研究科(研究院), 特任講師 (70343689)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脂肪細胞由来因子 / アディポネクチン / 心不全 / 腎不全 |
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| Research Abstract |
Adipose tissue functions as an endocrine organ by secreting adipocytokines that can directly affect nearby or remote organs. Adiponectin is an adipocytokine whose concentration is down-regulated in subjects with obesity-related disorders. Low levels of circulating adiponectin appear to associate with the increased prevalence of obesity-linked diseases including cardiac and renal dysfunction. In our study, we have shown that adiponectin exerts beneficial effects on the cardio-renal system by directly acting on the component cells in the heart and kidney. The cardiovascular protection by adiponectin is mediated through its ability to attenuate apoptotic activity in the target organs. Thus, adiponectin could represent a therapeutic target molecule for prevention or treatment of cardio-renal diseases.
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[Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation2013
Author(s)
Uemura Y, Shibata R, Ohashi K, Enomoto T,Kambara T, Yamamoto T, Ogura Y, Yuasa D,Joki Y, Matsuo K, Miyabe M, Kataoka Y,Murohara T and Ouchi N
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Journal Title
FASEB journal
Volume: 27
Pages: 25-33
Peer Reviewed
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[Journal Article] Therapeutic impact offollistatin-like 1 on myocardial ischemic injury in preclinical models2012
Author(s)
Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S,Yuasa D, Matsuo K, Enomoto T, Uemura Y,Miyabe M, Ishii M, Yamamoto T, Shimizu Y,Walsh K and Murohara T
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Journal Title
Circulation
Volume: 126
Pages: 1728-38
Peer Reviewed
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[Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism2012
Author(s)
Maruyama S, Shibata R, Kikuchi R, Izumiya Y,Rokutanda T, Araki S, Kataoka Y, Ohashi K,Daida H, Kihara S, Ogawa H, Murohara T and Ouchi N
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Journal Title
The Journal of biological chemistry
Volume: 287
Pages: 408-17
Peer Reviewed
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[Journal Article] CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism2012
Author(s)
Kambara T, Ohashi K, Shibata R, Ogura Y,Maruyama S, Enomoto T, Uemura Y, Shimizu Y,Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T and Ouchi N
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Journal Title
The Journal of biological chemistry
Volume: 287
Pages: 18965-73
Peer Reviewed
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[Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population2011
Author(s)
Tanimura D, Shibata R, Izawa H, Hirashiki A,Asano H, Murase Y, Miyata S, Nakatochi M,Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T and Yokota M.
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Journal Title
European journal of human genetics : EJHG
Volume: 19
Pages: 262-9
Peer Reviewed
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[Journal Article] Association of adiponectin with carotid arteriosclerosis in predialysis chronic kidney disease2011
Author(s)
Hayashi M, Shibata R, Takahashi H, Ishii H,Aoyama T, Kasuga H, Yamada S, Ohashi K,Maruyama S, Matsuo S, Ouchi N, Murohara T and Toriyama T
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Journal Title
American journal of nephrology
Volume: 34
Pages: 249-55
Peer Reviewed
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