2012 Fiscal Year Final Research Report
Non-invasive therapeutic angiogenesis for critical limb ischemia
| Project/Area Number |
23790884
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TARA Shuhei 日本医科大学, 医学部, 助教 (80465319)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 重症虚血肢 / 血管新生 / 体外衝撃波 |
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| Research Abstract |
We investigated the safety and efficacy of a low-energy shock waves therapy in order to develop a non-invasive method for intractable peripheral arterial disease. To assess microcirculation blood flow, transcutaneous oxygen tension (TcPO2), skin perfusion pressure (SPP) and 99mtechnetium-tetrofosmin (99mTc-TF) scintigraphy were performed before and after therapy. The value of TcPO2 and perfusion index using 99mTc-TF increased significantly. SPP tended to increase after therapy, but there was no significant difference. There was no adverse event such as bleeding and pain, despite all the patientsin this study were taking one or more antiplatelet agents.
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